Table 2.

Estimated Effect of SADT

Method and Matching Variables	Strata Size*	Hazard Ratio	95% CI
Two-Stage:
NA	NA	0.24	(0.17, 0.33)
Sequential Stratification:
PSA, location
0.2 Threshold	11.0 (1.0, 112.2)	0.29	(0.19, 0.43)
0.5 Threshold	28.0 (3.0, 281.4)	0.33	(0.23, 0.47)
1.0 Threshold	73.0 (7.2, 508.4)	0.44	(0.32, 0.61)
10-NN	11.0 (11.0, 11.0)	0.28	(0.20, 0.40)
PSA, sPSA, location
0.2 Threshold	3.0 (1.0, 30.0)	0.26	(0.15, 0.45)
0.5 Threshold	13.0 (1.0, 159.2)	0.25	(0.17, 0.38)
1.0 Threshold	42.0 (4.0, 370.8)	0.31	(0.22, 0.45)
10-NN	11.0 (11.0, 11.0)	0.29	(0.21, 0.41)
PSA, sPSA, LTP, location
0.2 Threshold	1.0 (1.0, 6.0)	0.37	(0.16, 0.87)
0.5 Threshold	5.0 (1.0, 71.8)	0.24	(0.15, 0.38)
1.0 Threshold	28.0 (2.0, 297.8)	0.31	(0.21, 0.44)
10-NN	11.0 (11.0, 11.0)	0.27	(0.19, 0.39)

^*Strata size is given by: median (5^th, 95^th percentiles)

Abbreviations: PSA indicates matching on standardized log(PSA + 0.1), sPSA indicates matching on standardized slope of log(PSA + 0.1), and LTP indicates matching on standardized long-term phase coefficient.