Fig. 5.
The effect of TB4 on oligodendrocyte progenitor cells (NG2+) in the injured cortex, ipsilateral CA3 and dentate gyrus 35 days after TBI. TBI alone (B, E, and H) significantly increases the number of NG2+ cells in the ipsilateral cortex, CA3 and dentate gyrus compared to sham controls (A, D, and G) (p < 0.05). TB4 treatment does not affect the number of NG2+ cells in these regions (C, F, and I; arrow as example showing NG2+ cell) compared to the saline-treated groups. The number of BrdU+ cells is shown in (J). Scale bar = 25μm (I, applicable to A–I). Data represent mean ± SD. *p < 0.05 vs Sham group. N (rats/group) = 6 (Sham); 9 (Saline); and 10 (TB4).