Fig. 2.

Complement factor H and complement factor H-related 1. The figure demonstrates the 20 CCP modules of factor H (bottom) and the five CCP modules of factor H-related protein 1 (top). The homology of each factor H-related protein 1 CCP to the corresponding factor H CCP is given as a percentage in the factor H-related protein 1 figure. Note the homology between CCP18 of factor H and CCP 3 of factor H-related protein 1 is given for the basic isoform. An acidic isoform differs by three amino acids [62]. The glycosaminoglycan and C3b binding sites of factor H are indicated on the diagram. Mutations in CFH reported in aHUS are listed below the figure