Table 5.
Five-year outcomes by anti-CCP antibody status*
| 5-year outcome | Anti-CCP antibody negative (n = 515) | Anti-CCP antibody positive (n = 214) | Anti-CCP antibody positive vs. anti-CCP antibody negative (adjusted by baseline) |
|---|---|---|---|
| HAQ score, median (IQR) | 0.625 (0–1.375) | 1.13 (0.5–1.875) | |
| Change in HAQ score, mean (95% CI)† | 0.005 (−0.06, 0.07) | 0.20 (0.09, 0.31) | |
| Mean difference (95% CI) | 0.27 (0.16, 0.39) | ||
| Swollen joint count, median (IQR) | 0 (0–2) | 3 (0–6.5) | |
| Change in swollen joint count since baseline, mean (95% CI)‡ | −7 (−8, −6) | −6 (−7, −4) | |
| Mean difference (95% CI) | 2.79 (1.98, 3.6) | ||
| Tender joint count, median (IQR) | 1 (0–6) | 2 (0–9.5) | |
| Change in tender joint count since baseline, mean (95% CI)‡ | −7 (−8, −5) | −4 (−6, −2) | |
| Mean difference (95% CI) | 2.54 (0.96, 4.12) | ||
| Swollen and tender joint count, median (IQR) | 0 (0–1) | 1 (0–4) | |
| Change in swollen and tender joint count since baseline, mean (95% CI)‡ | −4 (−5, −4) | −3 (−4, −1) | |
| Mean difference (95% CI) | 2.07 (1.35, 2.79) | ||
| DAS28 score, median (IQR) | 2.22 (1.42–3.09) | 3.09 (2.17–4.23) | |
| Change in DAS28 score, mean (95% CI)§ | −1.33 (−1.49, −1.17) | −0.92 (−1.25, −0.6) | |
| Mean difference (95% CI) | 0.78 (0.52, 1.05) | ||
| Satisfy ACR criteria cumulatively for RA, no. (%)¶ | 317 (61.6) | 205 (95.8) | |
| OR (95% CI) | 14.23 (7.13, 28.39) | ||
| Presence of erosions, no. (%)# | 135 (29.4) | 162 (80.6) | |
| OR (95% CI) | 9.97 (6.66, 14.92) |
Anti-CCP = anti–cyclic citrullinated peptide; HAQ = Health Assessment Questionnaire; IQR = interquartile range; 95% CI = 95% confidence interval; DAS28 = Disease Activity Score in 28 joints; ACR = American College of Rheumatology; RA = rheumatoid arthritis; OR = odds ratio.
Linear regression was used to compare outcomes between the groups. The HAQ was completed at baseline and 5 years by 710 subjects.
Linear regression was used to compare outcomes between the groups. Joints were examined at baseline and 5 years on 528 subjects.
Linear regression was used to compare outcomes between the groups. The DAS28 score was calculated at baseline and 5 years for 419 subjects.
Logistic regression was used to compare outcomes between the groups.
Logistic regression was used to compare outcomes between the groups. Radiographs were examined at baseline and 5 years on 660 subjects.