Skip to main content
. 2010 Aug;2(8):306–314. doi: 10.1002/emmm.201000082

Figure 1. CA1 hippocampal LTP impairment in APPPS1+ mice occurs at 4 months of age and is not regulated by PrPC expression.

Figure 1

  1. CA1 hippocampal LTP was induced in acute slices from 4-month-old Prnp+/+ mice (black, n = 7), but was abolished in slices from age-matched APPPS1+Prnp+/+ (dark blue, n = 6), APPPS1+Prnp+/o (blue, n = 5) and APPPS1+Prnpo/o mice (light blue n = 5).
  2. fEPSP traces before (red) and after (black) LTP induction. Calibration: 1 mV; 10 ms.
  3. Input–output curves (stimulus intensity vs. fEPSP slope) indicative of normal basal synaptic transmission.
  4. Unaffected LTP in slices derived from 2-month-old APPPS1+Prnp+/+ (n = 5), APPPS1+Prnp+/o (n = 5), APPPS1+Prnpo/o (n = 4) and Prnp+/o mice (n = 5). These results indicate that LTP impairment in APPPS1+ mice was not a developmental defect, and occurred only after 2 months of age independently of Prnp gene dosage.