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Effects of F 15845 Δ-KPQ -induced INap. (A) Experimental recordings of ΔKPQ-Nav1.5-induced INap in HEK293 cells in the absence and presence of 30 µM tetrodotoxin (TTX). INa-ΔKPQ was elicited at –10 mV from a holding potential value of –80 mV. (B) Effects of F 15845 at different concentrations on INa-ΔKPQ. (C) Steady-state inactivation curves of peak INa-ΔKPQ in the absence and presence of F 15845. Curves were obtained as described in Methods section. Data are means ± SEM of six cells.
