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. 2010 Sep;161(1):150–161. doi: 10.1111/j.1476-5381.2010.00875.x

Figure 4.

Figure 4

Competition radioligand binding for the WT AT1A receptor, AT1A-β-arrestin1 and AT1A-β-arrestin2. AT1A receptors were transiently expressed in COS-7 cells and competitive radioligand binding assays performed as described. [3H]-Ang II (10−9 M) (A, C–E) or [125I]-SI-ang II (10−11 M) (B) was used as radioligand tracers with the following unlabelled ligands: Ang II (A and B), Ang III (C) (Val4)Ang III (D) SII-Ang II (E) and telmisartan (F). Average pKi values are reported in Table 3. AT1, angiotensin II type 1; WT, wild type.