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. 2010 Sep;161(1):176–192. doi: 10.1111/j.1476-5381.2010.00878.x

Figure 3.

Figure 3

Role of COX in anandamide and S1P-mediated relaxation. Concentration–response curves for the vasorelaxant effect of anandamide alone (1 nM–30 µM, n= 13) and in the presence of indomethacin 10 µM in rat (A) endothelium-intact (n= 7) and in (B) endothelium-denuded (n= 6) U46619-pre-contracted CA. (C) Concentration–response curves showing the vasorelaxant effect of S1P alone (1 nM–30 µM, n= 10) and in the presence of indomethacin 10 µM (n= 4) in rat endothelium-intact U46619-pre-contracted CA. Data are expressed as a percentage of U46619-induced tone and shown as mean ± SEM for n arteries from different animals. *P < 0.05 versus anandamide or S1P alone as determined by two-way anova.