Table 3.

Effects of antagonist and enzyme inhibitors on S1P-mediated relaxation in rat CA

	pEC50	Rmax	n
S1P	−7.09 ± 0.3	46.10 ± 4.48	10
S1P (denuded)	−6.71 ± 0.77*	23.15 ± 6.82*	8
S1P	−7.09 ± 0.3	46.10 ± 4.48	10
S1P + W146 (10 µM)	−7.05 ± 0.58	34.74 ± 6.28	5
S1P	−7.01 ± 0.37	51.02 ± 6.02	10
S1P + JTE013 (10 µM)	−7.62 ± 0.35	55.79 ± 0.36	6
S1P	−7.09 ± 0.3	46.10 ± 4.48	10
S1P + CAY10444 (10 µM)	−7.99 ± 0.48	20.98 ± 2.65*	5
S1P	−7.09 ± 0.3	46.10 ± 4.48	10
S1P + indomethacin (10 µM)	−7.29 ± 2.39	9.22 ± 7.77*	4
S1P	−7.01 ± 0.37	51.02 ± 6.02	10
S1P + AM630 (10 µM)	−6.972 ± 0.42	23.48 ± 3.78*	6
S1P	−7.09 ± 0.3	46.10 ± 4.48	10
*S1P + JTE907 (10 µM)	−7.19 ± 0.39	18.51 ± 2.44*	5
S1P	−7.09 ± 0.3	46.10 ± 4.48	10
S1P + SKi (10 µM)	−7.82 ± 0.3	23.14 ± 4.52*	5

Data are expressed as mean ± SEM for n arteries from different animals.

^*P < 0.05 versus S1P alone as determined by two-way anova.