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Inhibition of hU-II-induced contraction of isolated aortae from hUT transgenic mice by (A) GSK1440115 and (B) GSK1562590. Whereas pretreatment with 10 000 nM GSK1440115 elicited a parallel, rightward shift in the hU-II concentration–response curve (consistent with competitive hU-II antagonism), 3 nM GSK1562590 abolished the contractile responses to hU-II.
