Table 9.

Inhibitory effects of GSK1562590 (1 mg·kg⁻¹, p.o.) on hU-II-induced contraction of rat aorta ex vivo

		hU-II pEC50		hU-II Emax (% 60 mM KCl)
Time (h)	Plasma concentration (nM)	Vehicle	GSK1562590	Vehicle	GSK1562590
2	1.10 ± 0.35	8.35 ± 0.07	8.07 ± 0.18	66 ± 37	23 ± 9*
16	<0.12 ± 0.04†	8.52 ± 0.05	8.27 ± 0.09*	64 ± 8	27 ± 5*
24	<0.07	8.46 ± 0.02	8.29 ± 0.09	106 ± 6	54 ± 16*
36	<0.07	8.65 ± 0.05	8.61 ± 0.05	117 ± 11	91 ± 14
48	<0.07	8.56 ± 0.05	8.49 ± 0.07	102 ± 9	102 ± 12

All values are expressed as mean ± SEM (n= 5–7).

^†Plasma concentrations below limit of detection (0.07 nM) for four out of six animals. Statistical comparisons of E_max and pEC₅₀ values were made using unpaired, two-tailed t-tests where

^*P < 0.05 versus vehicle.