Table 3.

Summary of 5 imputations of the model with imputed benign breast disease (BBD) categories and the average beta estimates, corresponding relative risk, and p-value

	Without BBD type	Model with BBD Categories included
		Imputation Number					Average
		1	2	3	4	5
	β (p-value)	β	β	β	β	β	β	P-value	1a	RR (95% CI)
Intercept	−8.96	−8.88	−8.90	−8.86	−8.88	−8.87	−8.88
Duration of premenopausal years	0.075 (<0.001)	0.073	0.073	0.072	0.073	0.073	0.073	<0.001	1	1.08 (1.07–1.09)
Age at first birth –age at menarche	0.0065 (0.18)	0.0066	0.0070	0.0067	0.007	0.0068	0.0068	0.06	10	1.07 (1.00–1.15)
Birth index	−0.0033 (0.01)	−0.0033	−0.0032	−0.0032	−0.0033	−0.0033	−0.0032	<0.001	102	0.72 (0.64–0.80)
Duration of natural menopause	0.020 (0.01)	0.017	0.017	0.017	0.017	0.017	0.017	0.08	1	1.02 (1.00–1.03)
Duration of bilateral oophorectomy	0.009 (0.16)	0.008	0.008	0.007	0.008	0.0074	0.0075	0.82	1	1.01 (0.95–1.07)
Prior BBD (Yes/No)	0.39 (<0.001)			-	-	-	-
Duration of E only PMH	0.033 (0.03)	0.030	0.031	0.031	0.031	0.032	0.031	<0.001	10	1.36 (1.20–1.55)
Duration of E+P PMH	0.062 (0.01)	0.062	0.062	0.062	0.062	0.062	0.062	<0.001	10	1.86 (1.52–2.27)
Duration of other PMH	0.026 (0.09)	0.025	0.025	0.025	0.025	0.025	0.025	0.007	10	1.28 (1.07–1.54)
Current use of PMH	0.027 (0.49)	0.031	0.035	0.032	0.034	0.035	0.033	0.56	1	1.03 (0.92–1.16)
Past use of PMH	−0.14 (0.12)	−0.14	−0.14	−0.14	−0.14	−0.14	−0.14	0.01	1	0.87 (0.78–0.97)
Average BMI Pre*duration premenopause	−0.0013 (<0.001)	−0.0013	−0.0013	−0.0013	−0.0013	−0.0013	−0.0013	<0.001	370b	0.61 (0.53–0.70)
Average BMI post*duration postmenopause	0.0039 (0.005)	0.0039	0.0038	0.0038	0.0038	0.0039	0.0038	<0.001	200c	2.16 (1.78–2.61)
Height* duration premenopause	0.00086 (0.06)	0.00088	0.00086	0.00086	0.00086	0.00087	0.00087	<0.001	222d	1.21 (1.09–1.35)
Height* duration postmenopause	−0.0010 (0.34)	−0.0011	−0.0011	−0.0010	−0.0012	−0.001	−0.0011	0.32	120e	0.88 (0.68–1.13)
Cumulative alcohol premenopause	0.00020 (0.06)	0.00021	0.00019	0.00020	0.00020	0.00020	0.00020	<0.001	384f	1.08 (1.04–1.12)
Cumulative alcohol postmenopause if PMH	0.00022 (0.32)	0.00018	0.00025	0.00020	0.00023	0.00022	0.00021	0.34	120g	1.03 (0.97–1.08)
Cumulative alcohol postmenopause no PMH	0.00030 (0.16)	0.00029	0.00030	0.00030	0.00031	0.00030	0.00030	0.04	240h	1.07 (1.00–1.15)
Family history of breast cancer	0.42 (0.003)	0.42	0.43	0.43	0.42	0.43	0.43	<0.001	1	1.53 (1.39–1.68)
Nonproliferative BBD	-	0.09	0.12	0.05	0.10	0.11	0.095	0.15	1	1.10 (0.97–1.25)
PWOA BBD	-	0.38	0.39	0.39	0.38	0.37	0.38	<0.001	1	1.47 (1.34–1.61)
Atypical hyperplasia BBD	-	1.12	1.04	1.15	1.10	1.13	1.11	<0.001	1	3.02 (2.57–3.55)
Unclassified BBD		0.40	0.40	0.40	0.40	0.40	0.40	<0.001	1	1.49 (1.31–1.69)

^aIncrement for RR comparison

^bComparing BMI=20 versus BMI=30 for 37 premenopausal years (age at menarche=13, age at menopause=50 years).

^cComparing BMI=20 versus BMI=30 for 20 postmenopausal years (age at menopause=50, age =70 years).

^dComparing height = 61 inches versus height = 67 inches for 37 premenopausal years (age at menarche=13, age at menopause=50 years).

^eComparing height = 61 inches versus height = 67 inches for 20 postmenopausal years (age at menopause=50, age =70 years).

^fComparing 1 drink per day (12 g) versus no intake for 32 premenopausal years (from age 18 to age 50 years).

^gComparing 1 drink per day (12 g) versus no intake for 10 years of PMH use.

^hComparing 1 drink per day (12 g) versus no intake for 20 postmenopausal years (age at menopause=50, age=70 years).