Table 2.
Association between use of antidepressant medications and colorectal cancer risk, Group Health, 2000-2003
| Cases (N=649) |
Controls (N=656) |
Minimally adjusted odds ratio (95% CI)1 |
Fully adjusted odds ratio (95% CI)1,2 |
|
|---|---|---|---|---|
| n (%) | n (%) | |||
| No antidepressant use | 521 (80.3) | 497 (75.8) | Reference | Reference |
| Any antidepressant use | 128 (19.7) | 159 (24.2) | 0.8 (0.6, 1.0) | 0.7 (0.5, 0.9) |
| SSRI use exclusively | 29 (4.5) | 40 (6.1) | 0.7 (0.4, 1.1) | 0.7 (0.4, 1.1) |
| TCA use exclusively | 47 (7.2) | 55 (8.4) | 0.8 (0.5, 1.2) | 0.7 (0.5, 1.1) |
| Other antidepressant use exclusively |
6 (0.9) | 16 (2.4) | 0.4 (0.1, 0.9) | 0.3 (0.1, 0.9) |
SSRI = selective serotonin reuptake inhibitors; TCA = tricyclic antidepressants; CI = confidence interval
1
Adjusted for matching factors: sex, age, and length of enrollment at Group Health prior to reference date
2
Also adjusted for smoking status, NSAID/aspirin dispensed from Group Health pharmacy or use noted in medical record, and history of diabetes mellitus