Table 3.

Association between use of antidepressant medications and colorectal cancer risk, according to duration and recency of use, Group Health, 2000-2003

	Cases (N=649)	Controls (N=656)	Minimally adjusted odds ratio (95% CI)1	Fully adjusted odds ratio (95% CI)1,2
	n (%)	n (%)
Non-users	521 (80.3)	497 (75.8)	Reference	Reference
Any antidepressant use
Duration of use <2 years, & current   use or last use <2 years before   reference	38 (5.9)	59 (9.0)	0.6 (0.4, 0.9)	0.5 (0.3, 0.8)
Duration of use <2 years, & last use   ≥2 years before reference	29 (4.5)	45 (6.9)	0.6 (0.4, 1.0)	0.6 (0.4, 1.0)
Duration ≥2 years	61 (9.4)	55 (8.4)	1.1 (0.7, 1.6)	1.0 (0.7, 1.5)
SSRI use exclusively
Duration of use <2 years	20 (3.1)	31 (4.7)	0.6 (0.3, 1.1)	0.6 (0.3, 1.1)
Duration of use ≥2 years	9 (1.4)	9 (1.4)	1.0 (0.4, 2.4)	1.0 (0.4, 2.8)
TCA use exclusively
Duration of use <2 years	29 (4.5)	42 (6.4)	0.6 (0.4, 1.0)	0.6 (0.3, 1.0)
Duration of use ≥2 years	18 (2.8)	13 (2.0)	1.3 (0.6, 2.7)	1.3 (0.6, 2.7)

SSRI = selective serotonin reuptake inhibitors; TCA = tricyclic antidepressants; CI = confidence interval

¹Adjusted for matching factors: sex, age, and length of enrollment at Group Health prior to reference date

²Also adjusted for smoking status, NSAID/aspirin dispensed from Group Health pharmacy or use noted in medical record, and history of diabetes mellitus