Fig. 1.

Cluster analysis using average linkage clustering by correlation of gene expression normalized to the mean expression levels of each gene in all samples. Volunteer groups are indicated on top: E, early diffuse cutaneous systemic sclerosis (dcSSc); L, late dcSSc; and C, healthy controls, whose cells were cultured in M, control cell culture medium or collagen type I (CI), same medium with type I collagen added. Colour-coding of relative gene expression levels from lower to higher is shown at the bottom.