Table 4.
Pharmacokinetic profile.
| Parameters | Item | After first infusion, n = 50 | After week 24 infusion, n = 17 |
|---|---|---|---|
| Cmax (g/l) | Arithmetic mean (s.d.) | 15·9(3·1) | 15·1(3·1) |
| Geometric mean(CV) | 15·6(19·1) | 14·9(20·2) | |
| Median(range) | 15·5(11·1–23·6) | 14·8(10·4–21·3) | |
| tmax†(h) | Arithmetic mean(s.d.) | 6·24(4·32) | 8·64(7·68) |
| Median(range) | 4·56(2·64–24·00) | 6·48(1·92–27·84) | |
| ti(h) | Arithmetic mean(s.d.) | 4·30(1·07) | 4·03(1·66) |
| Median(range) | 4·00(2·42–7·25) | 3·47(1·68–7·75) | |
| t1/2(days) | Arithmetic mean(s.d.) | 50·81(30·32) | 55·86(20·47) |
| Median(range) | 45·59(23·36–196·22) | 52·26(28·57–110·16) | |
| AUC(0–tz)(days × g/l) | Arithmetic mean(s.d.) | 251(97) | 234(114) |
| Geometric mean(CV) | 233(42) | 207(56) | |
| Median(range) | 261(75–520) | 179(71–467) | |
| AUC(0–∞)(days × g/l) | Arithmetic mean(s.d.) | 956(653) | 989(329) |
| Geometric mean(CV) | 840(49) | 941(34) | |
| Median(range) | 793(326–3830) | 950(564–1745) | |
| Clearance(ml/min) | Arithmetic mean(s.d.) | 28·9(16·9) | 19·9(13·3) |
| Geometric mean(CV) | 22·9(96·1) | 15·4(93·9) | |
| Median(range) | 26·7(1·3–76·6) | 16·5(3·6–46·6) |
†
tmax (d) was converted into tmax (h) for tabulation (i.e. factor 24). AUC, area under the curve; CV, geometric coefficient of variation; s.d., standard deviation.