Table 2.
Prevalence of complications and NOD2 polymorphisms among 285 international common variable immunodeficiency (CVID) patients.
| Complication |
||||||
|---|---|---|---|---|---|---|
| NOD2 genotype | Bronchiectasis | Autoimmunity | Granuloma | LIP | Splenomegaly | Enteropathy |
| Gly908Arg | 4 | 4 | 2 | 1 | 4 | 2 |
| Leu1007finsC | 10 | 7 | 1 | 0 | 8 | 1 |
| Arg702Trp | 14 | 7 | 3 | 2 | 3 | 0 |
| Total with at least one mutation | 26* | 17* | 6 | 3 | 14* | 3 |
| WT | 112 | 64 | 30 | 13 | 71 | 13 |
| Total | 138 | 81 | 36 | 16 | 85 | 16 |
*
Patients within these groups had multiple NOD2 polymorphisms. LIP: lymphoid interstitial pneumonitis; WT: wild-type.