Fig. 4.

Representative immunoelectronmicroscopy micrographs showing the subcellular localization of cathelin-related anti-microbial peptide (CRAMP) and lipoarabinomannan (LAM), in BALB/c mouse lung after 28 days of intratracheal infection with a high dose of Mycobacterium tuberculosis H37Rv to induce progressive disease. (a) Intracellular bacilli in alveolar macrophage showing CRAMP immunolabelling (small dots) and LAM (large dots) (×40 000). (b) Cytoplasmic subapical vacuoles in alveolar macrophage showing positive immunolabeling to CRAMP (small dots) and LAM (large dots) (×70 000).