Table 4.

Association analysis between non-responders and responders to MTX, across the SLC16A7 gene, in UK and US dataset.

SNP	Gene	CHR	Position	Minor allele	Major allele	UK MAF NR (n=51)	UK MAF ACR-Ped70 (n=72)	OR (95% CI)	P trend	US MAF NR (n=76)	US MAF Joint count 70 (n=67)	OR (95% CI)	P trend
rs17122830	SLC16A7	12	58359507	G	A	0.07	0.06	1.11 (0.40-3.07)	0.84	0.06	0.05	1.16 (0.42-3.2)	0.79
rs1497474	SLC16A7	12	58360056	T	C	0.27	0.27	0.99 (0.56-1.77)	0.98	0.22	0.28	0.76 (0.44-1.29)	0.3
rs10877327	SLC16A7	12	58360452	T	G	0.15	0.13	1.21 (0.58-2.52)	0.64	NT	NT
rs7976956	SLC16A7	12	58365097	A	G	0.25	0.23	1.12 (0.61-2.03)	0.73	NT	NT
rs1000708	SLC16A7	12	58369755	G	A	0.41	0.48	0.75 (0.44-1.29)	0.25	NT	NT
rs7971953	SLC16A7	12	58376474	C	G	0.20	0.26	0.70 (0.37-1.35)	0.28	0.25	0.28	0.87 (0.52-1.48)	0.62
rs12231740	SLC16A7	12	58390307	T	C	0.38	0.28	1.61 (0.94-2.76)	0.07	0.28	0.20	1.56 (0.9-2.71)	0.12
rs2711669	SLC16A7	12	58415239	T	C	0.09	0.07	1.45 (0.55-3.80)	0.43	0.07	0.04	1.5 (0.53-4.25)	0.46
rs2706301	SLC16A7	12	58421669	C	G	0.38	0.44	0.79 (0.46-1.36)	0.36	NT	NT
rs10877333	SLC16A7	12	58442313	G	T	0.12	0.22	0.48 (0.23-0.98)	0.03	0.21	0.25	0.83 (0.48-1.45)	0.51
rs2711655	SLC16A7	12	58452688	G	A	0.50	0.35	1.84 (1.10-3.09)	0.02	NT	NT
rs12718000	SLC16A7	12	58455532	A	G	0.09	0.09	0.91 (0.36-2.33)	0.84	NT	NT
rs3763980	SLC16A7	12	58459623	A	T	0.36	0.23	1.96 (1.11-3.44)	0.02	0.28	0.17	1.83 (1.01-3.31)	0.04
rs10784000	SLC16A7	12	58467231	G	A	0.28	0.28	1.00 (0.57-1.75)	0.99	NT	NT

NOTES : CHR=chromosome, MAF= minor allele, NR=non-responder; NT- not tested; significantly associated SNPs (p<0.05) in bold