Table 5.
Haplotype analysis across the LD block within SLC16A7.
| Haplotype | rs2706301 | rs10877333* | rs2711655* | rs12718000 | rs3763980* | rs10784000 | Haplotype Frequency. | Case,Control Frequencies | Chi Square | P Value |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | G | T | G | G | A | A | 0.28 | 0.36, 0.22 | 5.8 | 0.01 |
| 2 | C | T | A | G | T | G | 0.28 | 0.27,0.28 | 0.03 | 0.86 |
| 3 | G | G | A | G | T | A | 0.18 | 0.12,0.22 | 4.5 | 0.03 |
| 4 | C | T | A | G | T | A | 0.12 | 0.11,0.14 | 0.49 | 0.48 |
| 5 | G | T | G | A | T | A | 0.09 | 0.1,0.09 | 0.09 | 0.77 |
| 6 | G | T | G | G | T | A | 0.04 | 0.03,0.04 | 0.39 | 0.53 |
*
significantly associated SNPs (p<0.05); Haplotype 1 = ‘risk’ haplotype (associated with increased risk of non-response to MTX), and Haplotype 3 = ‘protective’ haplotype (associated with a good response to MTX).