Fig. 1.

Deep cerebellar nuclei (DCN) index in ataxia patients is smaller than expected when compared with control participant data. a Mean DCN index decreases with age, and is smaller in patients compared with controls (P < 0.001). b Age-adjusted DCN index is negatively correlated with ataxia scores in each patient group (P < 0.001). c Age-adjusted DCN index for each group. Although there is considerable overlap between the values in most of the groups, all patient subgroups showed significant differences in DCN index compared to controls (ICD vs. control = P < 0.03, OPCA vs. control = P < 0.002, SCA6 vs. control = P < 0.001). In particular, the SCA6 DCN indices are distinctly lower than the control group values