Figure 2.

CpG-ODNs altered the expression of CD62L and CD44 on CD4⁺ T cells and CD8⁺ T cells. TILs were collected from lung cancer patients (n = 16) and treated with CpG-ODNs or control CpG-ODNs as described in Materials and Methods. 1 × 10⁷ autologous TILs were transferred into the tumor bearing Balb/c nude mice with 100 ug CpG-ODNs or control CpG-ODNs through tail vein. Ten days later, the lymphocytes were isolated from tumor mass and the expression of CD62L (a) and CD44 (b) on CD4⁺ T cells and CD8⁺ T cells was analyzed by FACS. Representative data referring to the mean of data obtained from all the patients included in each group was shown. *P < .05.