Table 3.
Gln27Glu, β2-adrenoceptor polymorphisms: association with hypertension, metabolic syndrome (type2 diabetes (DM)), and obesity.
| Authors [reference number] | Year | Populations | Subjects | Associations with the polymorphism |
|---|---|---|---|---|
| Large et al. [40] | 1997 | Swedish | Caucasian women with a wide range of obesity | Association with obesity |
| Echwald et al. [66] | 1998 | Danish | Caucasian juvenile-onset obese men | No association with obesity |
| Hellström et al. [67] | 1999 | Swedish | Caucasian men and women | Association with obesity only in women |
| Kortner et al. [68] | 1999 | German | Caucasian with morbid obesity | No association with obesity |
| Xie et al. [44] | 2000 | USA | Black and white Americans | No associations with hypertension |
| The Quebec Family Study [41] | 2000 | Canada | Caucasian men and women | Association with obesity and hyperlipidemia |
| Hayakawa et al. [42] | 2000 | Japanese | 210 Japanese men from a population | No association with obesity |
| Candy et al. [45] | 2000 | England | Black African men (including 192 hypertensive and 123 normotensive men) | No association with hypertension |
| Meirhaeghe et al. [47] | 2000 | French | 1195 middle-aged Caucasian in the urban population | Association with obesity in men |
| Kato et al. [48] | 2001 | Japanese | 842 hypertensive and 633 normotensive subjects | Association with BP levels (hypertension) in NT |
| Kawamura et al. [69] | 2001 | Japanese | Japanese-Americans | No association with obesity or DM |
| Ukkola et al. [70] | 2002 | USA | 12 pairs of twins, Caucasians | Association with weight gain (obesity) |
| Kim et al. [51] | 2002 | Korean | Patients with type 2 DM | Association with obesity, DM, and hyperlipidemia |
| Gonzalez-Sanchez et al. [71] | 2003 | Spanish | 666 Caucasian-based study (including men and women) | Association with obesity only in men |
| The HERITAGE family study [49] | 2003 | Canada | Sedentary black and white men | Association with lower fat in obese white men |
| Pereira et al. [20] | 2003 | Brazilian | 1576 ethnically mixed population (including men and women) | No association with systolic BP or BMI |
| The Olivetti heart study [55] | 2004 | Italian | 993 middle-aged men (regardless of BP levels or BMI) | No association with obesity or hypertension |
| Tafel et al. [57] | 2004 | Germany | Extremely obese children | No association with obesity |
| Masuo et al. [21] | 2005 | Japanese | Nonobese, normotensive men | Association with BP elevation, but no association with IR |
| Trombetta et al. [59] | 2005 | Brazilian | Brazilian healthy women | Association with hypertension (blunted forearm vasodilation response) |
| Kurabayashi et al. [63] | 2006 | Japanese | PCOS women | Association with high prevalence of PCOS accompanying IR |
| Gjesing et al. [64] | 2007 | Dutch | 7808 white subjects | No association with hypertension or obesity |
| Masuo et al. [65] | 2007 | Japanese | 219 nonobese, normotensive men | No association with IR |
BP: blood pressure; BMI: body mass index; DM: diabetes mellitus; NIDDM: noninsulin-dependent diabetes mellitus; IR: insulin resistance; PCOS: polycystic ovary syndrome; NT: normotensive subjects.