Table 1.

A literature survey of gene expression changes after treatment of in vivo and in vitro rodent liver models with PPARγ agonists.

		IN VIVO														IN VITRO
	Ref.	[27]	[28]	[29]			[24]	[30]	[11]		[31]		[23]	[32]		[33]	[34]	[12]	[35]	[36]	[36]	[37]
	model	PPARα −/− mice PPARγ1 overexpression		AZIP	WT LKO	AZIP LKO	ob/ob	ZDF rats	WT mice	AZIP	WT	ap2/dta	sprague dawley rats	KKA	ob/ob	primary rat hepatocytes					c9 rat	aml-12 murine
	treatment	TRO 5 d 0.1% v/v	no treatment	ROSI 5 w 5 mg/kg/d			TRO 10 d 200 mg/ 100 g chow	GW 1929 7 d 5 mg/kg/d	ROSI 3 w 3 mg/kg/d		TRO 5 w 16.6 mg/g chow		ROSI 4 d 30 mg/ kg/d	ROSI 28 d 2.5 mg/kg/d and TRO 100 mg/kg/d d		TRO 6 h 10– 200 μM	TRO 24 h 5–50– 200 μM	TRO, ROSI, PIO, CIG 6 h–10 h 5–200 μM	TRO 24 h 25 μM	TRO, ROSI, PIO 24 h 10–50– 100 μM	TRO, ROSI, PIO, CIG 6 h–10 h 5–200 μM	TRO 5 d 5 μM
	method	affymetrix/q-PCR		northern blotting				northern blotting/ q-PCR			northern blotting			q-PCR		northern blotting	q-PCR	applied biosystem	q-PCR	q-PCR/eXpress		q-PCR
	Por																			+
Oxidative stress	Hmox1																	+		+	+
	Ephx2						−
	Nqo																			+	+
	Acox1			+	−	+
	Cox2																				+
	Serpine1	−
	Kif5b	+
Cell cycle, proliferation and death	Brca1	+
	Cdkn1c	+
	Gadd45a	−
	Kif24	+
	Gadd153																	+			+
	Atf3																	+
	Bcl2l11																	+
	Blnk																	+
	p21	+																			+
	Gadd45g																	+		+	+
	Cflar																	+
	Egr1																	+
	Emp2																	+
	Fem1b																	+
	Fhl2																	+
	Fos																	+
	Herpud1																	+
	Hmga1																	+
	Igfbp1																	+
	Igfbp6																	+
	Il7																	+
	Lats1																	+
	Mt1a																	+
	Nr1d1																	+
	Phlda1																	+
	Sfn																	+
	Skil																	+
	Stk17b																	+
	Bid3																	+
	Ckn1b																	+
	Cldnk4																	+
	Myd116																	+
	Trp53inp1																	+
	S100a10		+
	Kif5b	+
	Il7	−
	Actn1																+
	Cdh1																−
	Gsn																−
	Ucp2	+					+
	Fsp27	+	+
Lipid metabolism	Acaca			+	−	+
	Lipe		+
	Srebp1							0	0													+
	Fabp4	+	+				+			+												+
	Adfp			+	−	+
	Cd36	+	+	+	−	+	+
	Cpt1a			+	−	−	0		0	0
	Cpt1b			+	−	−	0		0	0
	Pex11a	+
	Acsl5							+
	Apoc3						0
	Dci							−
	Elovl4	+
	Fabp5	+
	Fasn			+	−	+		+		−												+
	Ldlr			+	+	−
	Lipc			+	+	+
	Acdl							−
	Thiolase		+					−
	Kiaa1881	+	+
	Lamb3		+
	Me1							+					+
	Mttp			−	−	−
	Peci							−
	Pnpla2	+
	Scd1			+	−	+				+
	Cyp1a1																		0
Xenobiotic metabolism	Cyp1a2	−																	0
	Cyp2b1																		+	+
	Cyp2b2																		+
	Cyp2b6																					+
	Cyp3a																		+
	Cyp3a1																			+		+
	Cyp3a3																+
	Cyp4b1		+
	Cyp4a10	+	+										+
	Cyp4a14	+	+
	Cyp51a1							+
	Gsta2	−	−
	G6pc							−
Carbohydrate metabolism	Pdk4	+
	Pepck							−
	Gk							+
	Irs2								−
	Pc	+	+					−
	Aqp7	+
	Abcb1		+
Transporters	Abcc3:																+
	Slco1b1	+
	Slco1b3																−
	Mdr2																+
	Slco4a1	+
	Slc25a1							+
	Nr1i3																+
Nuclear receptors	Hnf4a																−					−
	Ppara			+	−	+			0	0
	Pparg		+	+	−	+				+	−	+				+		+
	Cebpa																−
	Pparg1													+	+
	Pparg2														+
	Ces3		−
	Hspa1																	+
	Il6r																	+
	Vnn1	+
	Scd2																+
	Actg1							+
	Adipoq	+	+
	Cav1	+	+
	Cav2	+
	Cfd	+	+
	Lrp1			+	+	+
Miscellanous	Mapk		+
	Paqr7	+
	Tmem159	+
	Tpm2	+
	Aco						+
	Aox			+	+	+			+	+
	growth response protein												+
	Fdft1							+
	Hex												+
	Hmgcs2							−
	Igh-6							+
	Il8bp		−
	Ldh-a												+

+: up-regulated

−: down-regulated

0: not modulated

The case is empty when the gene has not been studied.