Table 2.
Residues involved in the ligand binding at human nAChR dimer interface
| Chain | α3β2 | α3β3 | α4β2 | α6α6 | α7α7 |
|---|---|---|---|---|---|
| A | TYR93 | TYR93 | TYR98 | TYR98 | TYR93 |
| SER148 | SER148 | SER153 | SER153 | SER148 | |
| TRP149 | TRP149 | TRP154 | TRP154 | TRP149 | |
| SER150 | SER150 | THR155 | THR155 | SER150 | |
| TYR151 | TYR156 | ||||
| ILE188 | ILE188 | ILE193 | |||
| TYR190 | TYR190 | TYR195 | TYR195 | TYR188 | |
| CYS190 | |||||
| CYS191 | |||||
| TYR197 | TYR197 | TYR202 | TYR202 | TYR195 | |
| B | TRP57 | TRP56 | TRP57 | TRP60 | TRP55 |
| THR59 | LYS58 | THR59 | ARG62 | GLN57 | |
| MET58 | |||||
| LYS79 | |||||
| LYS80 | |||||
| ARG79 | |||||
| SER108 | |||||
| ASN109 | LYS108 | ASN109 | LYS112 | ASN107 | |
| ALA110 | VAL109 | ALA110 | ALA113 | VAL108 | |
| VAL111 | ILE110 | VAL111 | LEU114 | LEU109 | |
| PHE119 | VAL118 | PEH119 | THR122 | GLN117 | |
| TRP120 | TRP119 | TRP120 | TRP123 | TYR118 | |
| LEU121 | THR120 | LEU121 | THR124 | LEU119 | |
| PRO121 | PRO122 | ||||
| ASP171 | ASP170 | ASP171 | ASP174 |