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Mitochondrial abnormality in the liver of transgenic Ren2 male rat at 12 weeks of age. A, The normal hepatic mitochondrial morphology in the Sprague–Dawley control male rat model at 12 weeks of age. B, Mitochondrial abnormality in morphology in the 12-week-old transgenic Ren2 male rat model of hypertension and insulin resistance. Note the swollen and decreased matrix density by transmission electronic microscopy. Magnification, ×25 000.
