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. Author manuscript; available in PMC: 2010 Oct 25.
Published in final edited form as: Circ Res. 2008 Feb 29;102(4):401–414. doi: 10.1161/CIRCRESAHA.107.165472

Figure 2.

Figure 2

Mitochondrial biogenesis in the transgenic Ren2 male rat at 10 weeks of age. A, The longitudinal normal myocardial mitochondrial morphology in the Sprague–Dawley control male rat model at 10 weeks of age. Note the orderly and linearly arranged sarcomeres (closed arrows) and subsarcolemmal (sarcoplasmic reticulum) mitochondria (open arrows). Normal intercalated disc (arrowheads). Magnification, ×10 000. Bar=500 nm. B, Mitochondrial biogenesis in the 10-week-old transgenic Ren2 untreated control (Ren2C) rats, which display insulin resistance and abnormalities in both systolic and diastolic cardiac functions. Note the biogenesis of increased myocardial interdigitating mitochondria. Also note the loss of the orderly and linearly arranged sarcomeres. Magnification, ×10 000. Bar=500 nm.