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Fold increase in luciferase expression induced by splicing redirection in HeLa pLuc705 cells over the conjugate concentration range 0.6−3.0 μM: (A) branched and linear RXR4-PNA705 derivatives, (B) branched and linear RXR6-PNA705 derivatives, and (C) branched RXR8-PNA705 derivatives (inset shows a comparison of RXR8-2B-PNA705 and linear RXR8-PNA705 over a different concentration range 0.3−1.2 μM).
