Table 1.
List of experiments contained in the EuroDia database
| Name | Group | Technology | References |
|---|---|---|---|
| Pancreatic islet implanted transgenic (expressing survivini) in mice | Public | Affymetrix | |
| Beta cells (MIN6) treated with amylin at different times and doses and growth at different concentrations of glucose | Public | Affymetrix | |
| Beta cell specific ablation of Foxa2 (HNF-3b) in mice | Public | Spotted | |
| MIN6 cells treated with Exendin-4 over time | Public | Spotted | |
| Pancreas versus islets | Public | Spotted | |
| Transcription profiling of mouse islet growth after partial pancreatectomy and exendin-4 treatment | Public | Spotted | |
| Mouse islets treated with PANcreatic DERived factor for 48 or 72 h | Public | Spotted | |
| Non-diabetic and diabetic obese mice—islets | Public | Affymetrix | |
| HSL KO and WT | Public | Spotted | |
| Tungstate-induced beta cell mass increase in STZ rats | Public | Affymetrix | |
| Identification of tissue restricted and interferon alpha regulated transcripts in human islet tissue | Public | Affymetrix | |
| LCM human islet beta cells | Public | Affymetrix | |
| Nestin positive cells versus human islets | Public | Affymetrix | |
| Pancreas versus islets | Public | Affymetrix | |
| Human pancreatic islets from normal and type 2 diabetic subjects | Public | Affymetrix | |
| Transcription profiling of HNF4 alpha null mice to investigate the phenotype of dis-regulated insulin secretion and abnormal beta cell growth | Public | Spotted | |
| Cyclophosphamide-induced beta Cell Destruction in NOD Mice | Public | Affymetrix | |
| PPAR gamma overexpression and activation in rat pancreatic islet | Public | Affymetrix | |
| Pancreatic beta cell lines overexpressing wild-type MODY genes or mutant HNF1b alleles | Public | Affymetrix | |
| Islet amyloid polypeptide effect on pancreatic cell line: time course and dose responsed | Public | Affymetrix | |
| Transcription profiling of rat pancreatic islets after culture in low, intermediate and high (glucose) | Public | Affymetrix | |
| Detailed transcriptome atlas of the pancreatic beta cell | Public | Affymetrix | |
| GSIS Study of Rat INS1 cell lines | Public | Spotted | |
| Lipotoxicity Study of Rat INS1 cell lines | Public | Spotted | |
| foxA1 and beta cell function | Public | Spotted | |
| Identification of novel cytokine induced genes in rat pancreatic beta-cells | Eizirik | Affymetrix | (26) |
| Global profiling of double stranded RNA- and IFN-gamma-induced genes in rat pancreatic beta cells | Eizirik | Affymetrix | (27) |
| Cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat beta-cells | Eizirik | Affymetrix | (28) |
| Global gene expression profiling in cytokine-treated rat pancreatic beta-cells | Eizirik | Affymetrix | (29) |
| Global alternative splicing profiling in cytokine-treated rat pancreatic beta-cells | Eizirik | Affymetrix | (29) |
| Gene expression differences between control and Tcf1/Hnf1alpha knock-out pancreatic islets | Ferrer | Affymetrix | (30) |
| Gene expression differences between control, Pancreas-specific Hnf4alpha knock-out(P-Hnf4aKO, mediated by expression of Pdx-1Cre transgen),Tcf1/Hnf1alpha heterozygous (Hnf1aHET) and double mutant (P-Hnf4a;Hnf1aHET) pancreatic islets | Ferrer | Affymetrix | (31,32) |
| Gene expression data from murine islet samples comparing transgenic mice with beta cell specific hormone sensitive lipase (HSL) overexpression with wild-type mice | Holm | Affymetrix | |
| Calcineurin inhibitors on human islets | Marchetti | Affymetrix | (33) |
| Type 2 diabetic versus non-diabetic islets | Marchetti | Affymetrix | |
| Beta cells of type 2 diabetic subjects versus beta cells of non-diabetic controls | Marchetti | Affymetrix | (34) |
| Islet S/A LF versus HF diet | Schuit | Affymetrix | (35) |
| Islet WT versus islets S/A control diet | Schuit | Affymetrix | (35) |
| HF-diet versus normal diet in islets of WT C57Bl6 mice | Schuit | Affymetrix | |
| Time-course HFD study in WT mice | Schuit | Affymetrix | |
| Double GIP-R + GLP1-R KO mice—pancreatic islets | Thorens | Spotted | (36,37) |
| Comparison GLP-1 or GLP-1+diazoxide treatment of betaTcTet cells for 7h. Pancreatic beta cell line | Thorens | Spotted | |
| Treatment of betaTcTet cells with GLP-1 (Glucagon-like peptide 1) for 0, 45 min, 3 h and 7 h | Thorens | Spotted | (38) |
| Direct comparison of GLP-1 and GIP treatment for 7 h on betaTcTet— Pancreatic beta cell line | Thorens | Spotted |
HSL: hormone sensitive lipase, KO: knock-out, WT: wild-type, LCM: laser capture microdissection, GSIS: glucose stimulated insulin secretion, S/A: eIF2-Ser51 is mutated to encode an alanine, LF: low fat, HF: high fat, HFD: high fat diet.