FIGURE 4.

Mutation of Kpna7 caused reproductivity reduction by inducing partial fetal lethality. A–D, uteri were isolated from Kpna7 mutation mice. A, one uterus isolated from a Kpna7 mutation mouse contained embryonic 7.5 day (E7.5) embryos. All the embryos were alive on E7.5. B, one uterus containing E12.5 embryos. Three embryos were alive but others had died and been absorbed. C and D, typical littermates observed in Kpna7 mutation mice. C shows E13.5 littermates isolated from one female. Six of 13 of the fetuses were alive. The other embryos had died and been absorbed. Arrows indicate one typical absorbed embryo and its placenta. D shows E16.5 littermates isolated from one female. Five fetuses were alive. Two residues were found.