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Summary of IL-17RA deletion mutant phenotypes
Shown is a summary of signal transduction mediated by IL-17RA deletion series. ND, not determined. +, competent for signaling; −, incompetent for signaling.
| IL-6 secretion | 24p3-luciferase | Act1 recruitment | TRAF6 ubiquitination | C/EBPδ mRNA | IκBζ mRNA | CXCL1 mRNA | |
|---|---|---|---|---|---|---|---|
| IL-17RA | + | + | + | +/− | + | + | + |
| Δ800 | + | + | ND | ND | ND | ND | ND |
| Δ665 | + | + | + | + | + | + | + |
| Δ645 | + | + | + | + | + | + | + |
| Δ625 | − | − | + | − | − | − | − |
| Δ605 | − | − | − | − | ND | ND | ND |
| Δ585 | − | − | − | ND | ND | ND | − |
| Δ426 | − | − | − | ND | ND | ND | ND |
