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Selective knockdown of MyD88 compromised NF-κB, TNF-α, and MTA1 expression. A, NF-κB promoter-luciferase activity in LPS-stimulated Raw cells with or without TIR-MyD88. B, TNF-α promoter-luciferase activity in LPS-stimulated Raw cells with or without TIR-MyD88. C, MTA1-promoter-luciferase activity and qPCR analysis of MTA1 mRNA expression in LPS-stimulated Raw cells with or without TIR-MyD88, a dominant negative mutant of MyD88.
