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Stages of hESdF induced regional differentiation in human and monkey ESC colonies. The in vitro differentiation stages (IVDS1, IVDS2, and IVDS3) of ESC colonies were defined by the temporal morphological change of human or monkey ESCs after replating onto hESdF feeders. IVDS1 colonies (days 1–5) resembled ESC colonies; IVDS2 colonies (days 6–10) contained central foci filled with flattened and spiky cells. IVDS3 colonies (days 10–15) contained hepatocyte-like cells. Scale bar, 50 μm.
