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Working model for the coordination of the epsin functions on endocytosis and signaling. Ligand binding to its specific receptor triggers recruitment of epsin as well as other endocytic proteins. Epsin interaction with RalBP1 leads to GTPase activation and signaling at sites of endocytosis (see text and Fig. 4A for details). The scheme does not depict all known interactions between the proteins represented in the scheme, and not all interactions depicted occur at the same time.
