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Wild-type sequence at the β-knee and the mutants. Alignments show sequences at the junction between I-EGF1 and I-EGF2 (A–D) and at the C1-C2 loops of I-EGF modules 2–4 (E). A, wild-type human sequences. B, swaps from different integrin subunits and I-EGF modules. C, insertions and deletions. D, computationally designed constructs. E, swaps into I-EGF3 and I-EGF4.
