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Flexibility of the C1-C2 loop of I-EGF2. A and B, C1-C2 loop and the region containing the C1-C5 and C2-C4 disulfides of αVβ3 (A) and αIIbβ3 (B), with 2Fo-Fc electron density contoured at 1 σ. C, residues in common between A and B, after superposition on all residues present in the I-EGF2 domains. Carbons of αVβ3 and αIIbβ3 are green and blue respectively, with the entire side chain of Cys in yellow.
