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Lack of correlation between STAC efficacy (EC1.5) and STAC affinity for TAMRA-peptide (Kd). Open circles denote compounds with Kd ≥ 100 μm. The gray bar highlights a series of compounds with Kd values that range from 2.5 to ≥100 μm but have the same EC1.5 value of around 0.3 μm. These determinations were all done in buffers containing no cosolvent.
