Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
22 and SRT1460 activate the SIRT1-catalyzed deacetylation of Ac-Arg-His-Lys-LysAc-X. A, X = Trp-NH2, EC1.5 = 1.9 μm; X = AMC, EC1.5 = 3.1 μm. B, X = Trp-NH2, EC1.5 = 5.0 μm, EC50 = 27 ± 8 μm, and RVmax = 4.1 ± 0.1; X = Phe-NH2, EC1.5 = 26 μm. These titrations represent 3–5 independent experiments, conducted over the course of several weeks. Each point is the mean ± S.D. from these experiments.
