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Summary of the effect of STACs on the SIRT1-catalyzed deacetylation of Ac-Arg-His-Lys-LysAc-X
[STAC]o = 5 μm, [peptide]o < Km, [NAD+] = 70 μm. Each entry represents the average of 3 independent experiments; S.D. <15%.
| X | Relative velocity |
|||
|---|---|---|---|---|
| SRT1460 | SRT1720 | SRT2183 | 22 | |
| AMC | 0.7 | 1.8 | 1.1 | 2.7 |
| NH2 | 1.0 | 1.0 | 1.1 | 0.7 |
| Ala-NH2 | 1.1 | 0.9 | 0.8 | 1.0 |
| Phe-NH2 | 1.4 | 1.3 | 1.7 | 1.1 |
| Trp-NH2 | 1.6 | 1.0 | 1.0 | 2.6 |
