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. 2010 Jul 30;285(43):33404–33412. doi: 10.1074/jbc.M110.114058

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — Mutations in the β3 intracellular domain destabilize Na_v1.3 inactivation. A, shown is a summary of the β3 intracellular domain mutants used in the electrophysiological analysis. Shown are mean channel availability plots (B) and difference curves for Na_v1.3 cells/no β3, Na_v1.3 cells/β3-WT, Na_v1.3 cells/β3-AP, and Na_v1.3 cells/β3-ΔSE using data from all cells (C). Means (± S.E.) were generated from the following sample numbers: Na_v1.3/no β3, n = 26; Na_v1.3/β3-WT, n = 15; Na_v1.3/β3-AP, n = 13; Na_v1.3/β3-ΔSE, n = 12.