FIGURE 2.

Objective comparison between H77_NS5b and J4_NS5b. Shown is a ribbon view of the H77_NS5b structure in the orientation of Fig. 1A and colored after ESCET comparison with J4_NS5b using a significance level of 5 σ (see the legend to Table 3). J4_NS5b_S556K was chosen for the comparison, as it is the best defined J4_NS5b structure available (Table 4, 〈esd〉 line) and conformationally identical to other J4_NS5b structures at this significance level (Table 4, numbers in parentheses). The conformational differences between H77_NS5b and J4_NS5b indicate two major blocks in the molecule; the first (434 residues) is colored blue, and the second (89 residues) is in green, with two smaller regions (cyan and magenta); red zones indicate flexible regions. Helix A of the fingertips and helix S of the thumb are labeled.