TABLE 4.

Pairwise conformational comparisons between four different views of J4_NS5b

Table definitions are as in Table 3. In crystal form O (variants O1 and O₂), the two molecules in the asymmetric unit are conformationally identical (not shown). The better-defined molecule B (lower 〈esd〉) is presented. Note that there are significant differences at 2.5 σ between molecules in crystal forms O1 (previously published, PDB code 1NB4), O₂, and T (this report) but not between wild type J4_NS5b and J4_NS5b_S556K (denoted J4*) in the same crystal packing environment (O₂, this report). Note also that with a tolerance of 5 σ, there are no significant conformational differences between any of the J4_NS5b molecules.

	J4_O1_B	J4*_O2_B	J4_O2_B	J4_T_A
〈esd〉 (Å)	0.12	0.08	0.13	0.14
J4_O1_B		78.0 (99.1)	88.1 (99.7)	88.5 (99.3)
J4*_O2_B			100.0 (100.0)	90.5 (98.9)
J4_O2_B				94.2 (99.3)
J4_T_A