Deoxyhemoglobin (a) and oxyhemoglobin (b) levels in the CNS region as measured by CWNIRS. Representative animals are shown. The change in oxyhemoglobin and deoxyhemoglobin are normalized to the 0.1 and -0.1 with the values at the time point of CN infusion cessation, respectively, to be easy to compare the recovery rate between control and cobinamide sulfite-treated animals. As shown, the return of oxy- and deoxyhemoglobin levels to baseline is dramatically improved after cobinamide sulfite injection, which is similar to findings using DOS in Fig. 2. Individual animal data from both control and cobinamide sulfite treated group are also available to view at the online web site. (Fig. 3c, 3d, 3e, and 3f)