Table 1.

Deoxyhemoglobin recovery times in peripheral tissues following cyanide infusion. Time constant values for deoxyhemoglobin recovery fitted by using an exponential model shown as mean SEM standard deviation. The time constant is the standard exponential decay constant representing the time to recover to 63.2% of baseline value. Analysis was performed using a two sample t-test assuming unequal variances, for the intramuscular cobinamide sulfite versus controls; p<0.05 for the difference in deoxyhemoglobin time constant between control and cobinamide sulfite-treated animals. Oxy- and deoxyhemoglobin recovery times in CNS region following cyanide infusion. CWNIRS Time constant values for cyanide recovery of oxyhemoglobin and deoxyhemoglobin fitted by using an exponential model shown as mean SEM standard deviation, with 95% confidence interval in parentheses. Analysis was performed using two sample t-test assuming unequal variances; time constant p values for intramuscular cobinamide sulfite versus controls were <0.05 for both oxy- and deoxyhemoglobin. Slope of recovery versus time for deoxy- and oxyhemoglobin in the critical first 10 minutes after treatment. The above results are from fitting the initial 10 minutes of hemodynamic recovery in CNS after cobinamide sulfite administration shown as mean SEM standard deviation, with 95% confidence interval in parentheses. DPF is a differential pathlength factor (see the materials and methods section)

	Control (n=5)	Cobinamide sulfite (n=6)	95% CI for the mean differences
Recovery time to 63% of baseline values (minutes)
Peripheral Muscle
Deoxyhemoglobin, mean (SD)	76 (42.7)	24 (14.7)	7 to 98
CNS
Deoxyhemoglobin, mean (SD)	1032 (610)	9 (2.5)	116 to 1,874
Oxyhemoglobin, mean (SD)	261 (225)	10 (1.6)	28 to 358
Slope of the first 10 minutes recovery times (□M/DPF/minutes)
Deoxyhemoglobin, mean (SD)	0.6 (0.4)	2.3 (0.8)	0.9 to 2.5
Oxyhemoglobin, mean (SD)	−1.1 (0.3)	−4.4 (1.2)	2.1 to 4.5