TABLE 1.
Case no. | Age (yr)/sex | Primary disease | Period of onset of EBV syndrome following transplant (days) | Presenting clinical features | Outcome of initial EBV syndrome | Recurrent EBV syndromes | Final outcome of EBV infection |
---|---|---|---|---|---|---|---|
1 | 53/M | CC | 63 | Fever, pharyngitis, cervical and axillary LN | Resolution over 5 wk | PTLD lung and ileum resolved over 8 wk | Resolution |
2 | 22/M | PSC | 43 | Fever, pharyngitis generalized LN, Sp, icterus | Resolution over 8 wk | NIL | Resolution |
3 | 44/F | CC | 14 | Fever, generalized LN, icterus | Resolution over 8 wk | NIL | Resolution |
4 | 28/F | CC | 27 | Arthralgia right knee, petechial rash | Resolution over 2 wk | Systemic PTLD, fatal over 1 mo | Death |
5 | 20/M | CC | 603 | Fever, pharyngitis, paratracheal LN, diarrhea, jaw pains, arthralgias, right pleural effusion, Sp | Developed systemic PTLD, death at 8 wk | Death | |
6 | 58/M | Alcoholic cirrhosis | 31 | Fever, cervical and axillary LN | Resolution over 2 wk | Meningoencephalitis resolving over 5 days | Resolution |
7 | 26/F | α-1ATD | 74 | Icterus, axillary LN | Resolution over 3 wk | Systemic PTLD responsive to immunomodulation | Resolution |
8 | 18/F | Wilson’s | 10 | Fever, sinus headaches generalized LN | Resolution over 3 wk | NIL | Resolution |
9 | 54/M | CAH-B hepatoma | 36 | Fever, generalized LN | Developed systemic PTLD, fatal over 2 wk | Not applicable | Death |
10 | 42/F | CAH cirrhosis | 623 | Fever, pharyngitis, generalized LN, Sp, ascites, dysarthria, dysmetria, pneumonitis | Resolved over 11 wk | NIL | Resolution |
CC, cryptogenic cirrhosis; PSC, primary sclerosing cholangitis; CAH, chronic active hepatitis; α-1ATD, α-1antitrypsin deficiency; LN, lymphadenitis; Sp, splenomegaly; PTLD, posttransplant lymphoproliferative disorders.