Table 2.
Weighted-risk (FG raising) allele frequencies of 16 FG-associated SNPs by race/ethnicity, NHANES III DNA Bank (1991–1994)
| SNP | Chromosome | Nearest gene | Risk allele (effect/other)† | Risk allele frequency % (95% CI)* |
||
|---|---|---|---|---|---|---|
| Non-Hispanic white | Non-Hispanic black | Mexican American | ||||
| rs340874 | 1 | PROX1 | C/T | 52.4 (48.9–55.9) | 21.9 (19.2–24.8) | 41.2 (38.2–44.2) |
| rs573225 | 2 | G6PC2 | A/G | 69.9 (67.7–72.1) | 92.6 (90.9–93.9) | 82.6 (79.8–85.1) |
| rs780094 | 2 | GCKR | C/T | 58.3 (55.9–60.6) | 80.8 (78.7–82.7) | 65.1 (62.1–67.9) |
| rs11708067 | 3 | ADCY5 | A/G | 77.8 (75.4–80.0) | 85.3 (83.2–87.2) | 72.4 (69.8–75.0) |
| rs11920090 | 3 | SLC2A2 | T/A | 85.4 (83.8–86.8) | 66.0 (63.8–68.1) | 86.5 (84.0–88.7) |
| rs2191349 | 7 | DGKB | T/G | 54.7 (52.7–56.6) | 57.9 (55.8–59.9) | 41.9 (38.2–45.7) |
| rs4607517 | 7 | GCK | A/G | 17.1 (15.3–18.9) | 9.4 (7.6–11.7) | 21.8 (19.8–23.8) |
| rs11558471 | 8 | SLC30A8 | A/G | 69.0 (65.6–72.2) | 88.7 (86.9–90.3) | 72.9 (70.7–75.0) |
| rs7034200 | 9 | GLIS3 | A/C | 51.3 (48.9–53.7) | 62.6 (60.3–64.8) | 52.3 (50.4–54.2) |
| rs10885122 | 10 | ADRA2A | G/T | 86.1 (84.7–87.4) | 34.9 (32.6–37.2) | 82.9 (80.8–84.9) |
| rs7903146 | 10 | TCF7L2 | T/C | 29.1 (26.8–31.6) | 26.7 (25.3–28.2) | 18.0 (16.3–19.8) |
| rs10830963 | 11 | MTNR1B | G/C | 28.0 (25.8–30.3) | 7.9 (6.4–9.8) | 21.1 (18.5–24.0) |
| rs174550 | 11 | FADS1 | T/C | 66.5 (63.9–69.0) | 89.8 (87.6–91.6) | 39.2 (34.5–44.1) |
| rs11605924 | 11 | CRY2 | A/C | 48.3 (45.5–51.2) | 85.4 (83.3–87.3) | 50.0 (46.5–53.6) |
| rs7944584 | 11 | MADD | A/T | 71.4 (68.9–73.8) | 93.7 (91.7–95.3) | 84.3 (82.0–86.3) |
| rs11071657 | 15 | C2CD4B | A/G | 64.2 (62.0–66.4) | 86.4 (83.7–88.6) | 49.2 (46.1–52.3) |
*All SNPs were in HWE.
†FG-raising allele (effect) is denoted first.