Table 3.
Adjusted mean FG levels and HOMA-B by quintiles of weighted genetic risk score and race/ethnicity, NHANES III DNA Bank (1991–1994)
| Characteristics | β-Coefficient* | P value† | Quintiles of the 16 SNP weighted genetic risk score |
P value‡ |
R
2
§
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | Without score | With score | ||||
| Non-Hispanic white‖ | ||||||||||
| n | 286 | 131 | 300 | 251 | 186 | |||||
| GRS range | 0–15 | 16 | 17–18 | 19–20 | ≥21 | |||||
| FG (mmol/l) | 0.022 (0.009–0.035) | 0.002 | 5.10 (5.05–5.14) | 5.18 (5.08–5.27) | 5.18 (5.10–5.25) | 5.20 (5.13–5.26) | 5.28 (5.20–5.35) | 0.005 | 0.208 | 0.229 |
| HOMA-B | −3.54 (−7.21 to 0.13) | 0.058 | 136.8 (106.9–166.8) | 120.3 (100.7–139.9) | 117.0 (106.8–127.2) | 128.4 (108.5–148.2) | 102.1 (92.1–112.1) | 0.055 | 0.013 | 0.031 |
| Non-Hispanic black‖ | ||||||||||
| n | 160 | 114 | 178 | 258 | 111 | |||||
| GRS range | 0–16 | 17 | 18 | 19–20 | ≥21 | |||||
| FG (mmol/l) | 0.036 (0.019–0.052) | <0.001 | 5.04 (4.96–5.11) | 5.06 (4.95–5.17) | 5.06 (4.95–5.17) | 5.15 (5.07–5.24) | 5.26 (5.19–5.33) | <0.001 | 0.115 | 0.133 |
| HOMA-B | −4.98 (−8.32 to −1.64) | 0.005 | 170.6 (152.0–189.2) | 161.9 (131.3–192.4) | 170.7 (150.4–191.0) | 154.2 (135.0–173.4) | 133.9 (119.3–148.6) | 0.003 | 0.064 | 0.078 |
| Mexican American‖ | ||||||||||
| n | 209 | 106 | 139 | 205 | 186 | |||||
| GRS range | 0–15 | 16 | 17 | 18–19 | ≥20 | |||||
| FG (mmol/l) | 0.033 (0.020–0.046) | <0.001 | 5.11 (5.00–5.21) | 5.27 (5.19–5.36) | 5.24 (5.13–5.34) | 5.22 (5.10–5.34) | 5.37 (5.29–5.45) | <0.001 | 0.135 | 0.165 |
| HOMA-B | −4.10 (−7.17 to −1.03) | 0.011 | 160.5 (139.9–181.2) | 153.5 (142.1–164.8) | 160.5 (130.8–190.1) | 141.1 (120.4–161.7) | 127.2 (117.9–136.6) | 0.005 | 0.043 | 0.054 |
Data and 95% CIs in parentheses.
*β-Coefficients (95% CIs) of linear regression models adjusted for age and sex.
†P values for β-coefficients are based on Satterthwaite adjusted F test.
‡P values for testing difference in FG levels or HOMA-B across quintiles of weighted genetic risk score are based on Satterthwaite adjusted F statistics.
§Adjusted R2 for regression models with and without (age and sex only) weighted genetic risk score.
‖P = 0.291 and P = 0.637 for testing heterogeneity of weighted genetic risk score on FG levels and HOMA-B, respectively, across racial/ethnic groups are based on Satterthwaite adjusted F statistics.