Table 1.
Association between fetuin-A and abnormal albuminuria
| Unadjusted | Model 1 | Model 2 | Model 3 | Model 4 | |
|---|---|---|---|---|---|
| Men (n = 607) | |||||
| Quartile 1 (<235.6 mg/l) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| Quartile 2 (235.6–292.5 mg/l) | 1.18 (0.39–3.61) | 1.62 (0.44–6.02) | 2.25 (0.51–9.56) | 2.21 (0.52–9.45) | 2.18 (0.48–9.86) |
| Quartile 3 (292.5–368.6 mg/l) | 1.08 (0.62–1.89) | 0.98 (0.52–1.87) | 0.68 (0.32–1.43) | 0.69 (0.33–1.46) | 0.59 (0.25–1.37) |
| Quartile 4 (≥ 368.6 mg/l) | 1.06 (0.73–1.53) | 1.03 (0.67–1.57) | 0.97 (0.59–1.57) | 0.93 (0.57–1.53) | 0.90 (0.54–1.52) |
| Pfor trend | 0.79 | 0.88 | 0.63 | 0.60 | 0.45 |
| 1 SD increase of fetuin-A | 0.89 (0.54–1.28) | 0.80 (0.47–1.21) | 0.75 (0.42–1.12) | 0.74 (0.41–1.19) | 0.70 (0.38–1.16) |
| Women (n = 1,042) | |||||
| Quartile 1 (<233.9 mg/l) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) |
| Quartile 2 (233.9–283.0 mg/l) | 1.28 (0.57–2.88) | 1.12 (0.48–2.60) | 1.10 (0.47–2.58) | 1.08 (0.46–2.53) | 1.09 (0.46–2.58) |
| Quartile 3 (283.0–355.6 mg/l) | 1.26 (0.85–1.85) | 1.27 (0.85–1.91) | 1.28 (0.85–1.91) | 1.27 (0.85–1.91) | 1.27 (0.85–1.91) |
| Quartile 4 (≥355.6 mg/l) | 1.36 (1.07–1.73) | 1.37 (1.07–1.76) | 1.39 (1.08–1.80) | 1.40 (1.08–1.81) | 1.40 (1.08–1.81) |
| P for trend | 0.008 | 0.01 | 0.01 | 0.02 | 0.02 |
| 1 SD increase of fetuin-A | 1.30 (1.05–1.58) | 1.28 (1.02–1.56) | 1.26 (1.01–1.55) | 1.26 (1.01–1.55) | 1.26 (1.01–1.55) |
Data are OR (95% CI). We defined participants with the normal UAE as 0 and abnormal albuminuria (microalbuminuria and macroalbuminuria) as 1. Model 1: adjusted for age, family history of diabetes, smoking habits, and alcohol intake, systolic blood pressure, diastolic blood pressure, serum high-sensitivity-C-reactive protein, and eGFR; Model 2: further adjusted for serum triglyceride, total cholesterol, HDL cholesterol, and LDL cholesterol based on Model 1; Model 3: further adjusted for homeostasis model assessment of insulin resistance based on Model 2; Model 4: further adjusted for BMI and waist circumference based on Model 3.