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FGF21 resistance manifests early during weight gain. To test whether FGF21 resistance precedes the onset of obesity, mice were fed a high-fat diet for 4 weeks. At this time, mice were analyzed for FGF21 resistance via acute intraperitoneal injection of 150 ng/g of FGF21. Weights (A), hepatic FGF21-induced EGR1 expression (B), WAT EGR1 (C), and GLUT1 expression (D) are shown. Data are displayed as the mean ± SE. *P < 0.05.
