TABLE 2.
Clinical and biologic characteristics of obese subjects before surgery, 3 months, 6 months, and 1 year after surgery
| Before bypass | 3 Months after bypass | 6 Months after bypass | 1 Year after bypass | Mannová (P value) | |
|---|---|---|---|---|---|
| Adiposity markers | |||||
| Body weight(kg) | 135.03 ± 3.08 | 111.75 ± 2.84 | 102.04 ± 2.67 | 93.39 ± 2.72 | < 0.0001 |
| BMI (kg/m2) | 48.21 ± 0.82 | 39.78 ± 0.78 | 36.28 ± 0.78 | 33.30 ± 0.83 | < 0.0001 |
| Fat mass (% weight) | 46.21 ± 0.69 | 43.15 ± 0.71 | 39.24 ± 0.84 | 34.53 ± 0.89 | < 0.0001 |
| Leptin (ng/ml) | 63.05 ± 3.16 | 32.85 ± 2.15 | 23.9 ± 1.74 | 18.53 ± 0.89 | < 0.0001 |
| Plasma glucose homeostasis | |||||
| Glycaemia (mmol/l) | 6.55 ± 0.37 | 5.18 ± 0.13 | 4.87 ± 0.14 | 4.74 ± 0.11 | < 0.0001 |
| Insulinemia (mU/ml) | 19.02 ± 1.81 | 8.7 ± 0.47 | 6.9 ± 4.36 | 7.23 ± 0.99 | < 0.0001 |
| Adiponectin (μg/ml) | 6.08 ± 0.36 | 7.77 ± 0.43 | 9.95 ± 0.83 | 10.26 ± 0.67 | < 0.0001 |
| Diabetic (%)* | 32.3 | 14.3 | 9.5 | 8.6 | < 0.005 |
| Plasma lipid homeostasis | |||||
| Total cholesterol (mmol/l) | 5.00 ± 0.12 | 4.47 ± 0.11 | 4.36 ± 0.11 | 4.28 ± 0.10 | < 0.0001 |
| Total triglycerides (mmol/l) | 1.53 ± 0.10 | 1.22 ± 0.06 | 1.08 ± 0.06 | 0.89 ± 0.04 | < 0.0001 |
| HDL cholesterol (mmol/l) | 1.28 ± 0.05 | 1.23 ± 0.04 | 1.35 ± 0.05 | 1.50 ± 0.04 | < 0.0001 |
| Liver test | |||||
| AST | 24.51 ± 1.49 | 28.13 ± 1.59 | 26.33 ± 5.85 | 21.18 ± 1.03 | 0.0035 |
| ALT | 35.46 ± 3.49 | 38.31 ± 3.32 | 25.33 ± 2.59 | 24.27 ± 4.29 | 0.0287 |
| GGT | 48.90 ± 5.26 | 29.75 ± 2.90 | 40.38 ± 17.55 | 22.66 ± 2.13 | < 0.0001 |
| Inflammatory markers | |||||
| Plasma hsCRP (mg/l) | 0.91 ± 0.08 | 0.61 ± 0.09 | 0.39 ± 0.05 | 0.33 ± 0.11 | < 0.0001 |
| Plasma IL-6 (pg/ml) | 3.94 ± 0.32 | 3.46 ± 0.29 | 3.22 ± 0.39 | 2.27 ± 0.38 | 0.62 |
*Statistical analysis with McNemar χ2 test for noncontinuous measures. AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl transferase.